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Extramammary Paget Disease Anal Cancer

However, some doctors now use in vivo reflectance confocal microscopy RCM  which can also help determine the extent of EMPD with digital "virtual biopsies". The true incidence is still unclear but Karam and Dorigo found the median age at diagnosis to be 72 years with EMPD predominately occurring in Caucasians and women having a higher occurrence than men. James Paget described Paget's disease of the nipple in We want to hear from you.

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We hope this information is helpful. Perianal disease, invasion into the dermal skin layer, and spread of cancer to lymph nodes are more likely to be associated with a poor prognosis. Local recurrence occurs in half of patients with tumor-free margins by frozen section; long-term follow-up is warranted. Extramammary Paget's disease is a rare cutaneous adenocarcinoma, usually of epidermal origin and glandular differentiation and frequently associated with an underlying adnexal carcinoma and perhaps with underlying internal malignancy. One case involving EMPD of the scrotum reported successful treatment with radiation therapy over a 3 month period after failure of local excision and imiquimod therapy [ 8 ].




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We conclude that patients with extramammary Paget's disease have excellent survival but that local recurrence and morbidity from surgery, especially in the elderly, can be high. What are the symptoms of extramammary Paget disease? Table of Contents Alerts.


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A biopsy will establish the diagnosis. Perianal disease, dermal invasion, and two or more lymph node metastases are poor prognostic indicators. He is also taking Albuterol and Symbicort for reactive airway disease. How to Find a Disease Specialist.


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